CYP2E1

Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.14.1), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. While it is involved only in the oxidative metabolism of a small range of substrates (mostly small polar molecules), there are many important drug interactions mediated by CYP2E1.

Additional recommended knowledge

Daily Sensitivity Test

Essential Laboratory Skills Guide

Daily Visual Balance Check

CYP2E1 Ligands

Regulation of CYP2E1

Within one day of birth, the rat hepatic CYP2E1 gene is activated transcriptionally. CYP2E1 expression is easily inducible. It seems that there exist two stages of induction, a posttranslational mechanism for increased protein stability at low levels of ethanol, and an additional transciptional induction at high levels of ethanol^[4]

See also

• cytochrome
• metabolism

References

1. ^ Where classes of agents are listed, there may be exceptions within the class
2. ^ Mentioned both in the reference named FASS and were previously mentioned in Wikipedia. Further contributions may follow other systems
3. ^ Swedish environmental classification of pharmaceuticals Facts for prescribers (Fakta för förskrivare)
4. ^ Charles S. Lieber. 1999. Microsomal Ethanol-Oxidizing System (MEOS) The First 30 Years (1968-1998)-A Review. Alcoholism: Clinical and Experimental Research 23(6):991-1007