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CTGF
CTGF (connective tissue growth factor) is a cysteine-rich, matrix-associated, heparin-binding protein. In vitro, CTGF mirrors some of the effects of TGF beta on skin fibroblasts, such as stimulation of extracellular matrix production, chemotaxis, proliferation and integrin expression. CTGF can promote endothelial cell growth, migration, adhesion and survival and is thus implicated in endothelial cell function and angiogenesis[1]. CTGF binds to perlecan[2], a proteoglycan which has been localised in synovium, cartilage and numerous other tissues. CTGF has been implicated in extracellular matrix remodelling in wound healing, scleroderma and other fibrotic processes, as it is capable of upregulating both matrix metalloproteinases (MMPs) and their inhibitors (TIMPs). Therefore, CTGF has the potential to activate both the synthesis and degradation of the extracellular matrix. Knockout mice which have had the gene for CTGF removed do not develop normally. Impaired chondrocyte proliferation, angiogenesis, extracellular matrix production and turnover leads to abnormal skeletal growth.[3] References
Further reading
Categories: Genes on chromosome 6 | Human proteins | Growth factors |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CTGF". A list of authors is available in Wikipedia. |