CDGSH iron sulfur domain


Crystallographic structure (PDB 2QH7) of the CDGSH-type domain 1 dimer (green and cyan cartoon) complexed with iron (brown) and sulfur (yellow) Fe-S clusters.
CDGSH iron sulfur domain 1
Identifiers
Symbol	CISD1
Alt. Symbols	C10orf70, ZCD1
Entrez	55847
HUGO	30880
PDB	2QH7
RefSeq	NM_018464
UniProt	Q9NZ45
Other data
Locus	Chr. 10 q21.3

CDGSH iron sulfur domain 1B
Identifiers
Symbol	CISD1B
Alt. Symbols	ZCD1B
Entrez	130500
HUGO	29611
RefSeq	XM_065750
Other data
Locus	Chr. 2 p24.1

CDGSH iron sulfur domain 2
Identifiers
Symbol	CISD2
Alt. Symbols	ZCD2
Entrez	493856
HUGO	24212
RefSeq	NM_001008388
UniProt	Q7Z3D5
Other data
Locus	Chr. 4 q24

CDGSH iron sulfur domain 3
Identifiers
Symbol	CISD3
Entrez	284106
HUGO	27578
Other data
Locus	Chr. 17 q12

The CDGSH iron sulfur domain are a group of iron-sulfur (Fe-S) clusters and a unique 39 amino acid CDGSH domain [C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H].

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The CDGSH iron sulfur domain 1 protein (also referred to as mitoNEET) is an integral membrane protein located in the outer mitochondrial membrane and whose function may be to transport iron into the mitochondria.^[1] Iron in turn is essential for the function of several mitochondrial enzymes.

The antidiabetic drug pioglitazone, in addition to binding to the nuclear receptor PPAR, also has been shown to bind mitoNEET with approximately equal affinity.^[2]

References

^ Paddock ML, Wiley SE, Axelrod HL, Cohen AE, Roy M, Abresch EC, Capraro D, Murphy AN, Nechushtai R, Dixon JE, Jennings PA (2007). "MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone". Proc. Natl. Acad. Sci. U.S.A. 104 (36): 14342-7. doi:10.1073/pnas.0707189104. PMID 17766440.
^ Colca JR, McDonald WG, Waldon DJ, Leone JW, Lull JM, Bannow CA, Lund ET, Mathews WR (2004). "Identification of a novel mitochondrial protein ("mitoNEET") cross-linked specifically by a thiazolidinedione photoprobe". Am. J. Physiol. Endocrinol. Metab. 286 (2): E252-60. doi:10.1152/ajpendo.00424.2003. PMID 14570702.