Bile salt dependent lipase

carboxyl ester lipase (bile salt-stimulated lipase)
Identifiers
Symbol	CEL
Alt. Symbols	BSSL
Entrez	1056
HUGO	1848
OMIM	114840
RefSeq	NM_001807
UniProt	P19835
Other data
EC number	3.1.1.3
Locus	Chr. 9 q34.3

Bile salt dependent lipase (or BSDL) is an enzyme produced by the adult pancreas and aids in the digestion of fats. Bile salt stimulated lipase (or BSSL) is an equivalent enzyme found within breast milk. BSDL has been found in the pancreatic secretions of all species in which it has been looked for. BSSL, originally discovered in the milk of humans and various other primates, has since been found in the milk of many animals including dogs, cats, rats and rabbits.^[1]

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Enzymatic activity

More than 95% of the fat present in human milk and in infant formulas is in the form of triacylglycerols (TG).^[2] In adults TGs are mainly thought to be broken down or hydrolized by the colipase-dependent lipase enzyme. In the newborn, CDL activity in the duodenum is lower than in adults.^[2]

Both BSDL and BSSL have a broad substrate specificity and like CDL are capable of hydrolyzing triacylglycerides (in addition to phospholipids, esters of cholesterol and lipid soluble vitamins). BSDL production in the newborn pancreas is quite low when compared with production in the mammary gland or adult pancreas.^[3]

However newborn infants absorb lipids relatively well, considering the low level of CDL and BSDL they produce. This observation has led to the suggestion that BSDL produced by lactating mammary gland and present within milk, may compensate for the low levels of other TG digesting enzymes and aid newborns in lipid absorption.

References

^ Swan, JS, Hoffman MM. et al. (1992). "Two forms of human milk bile-salt-stimulated lipase". Biochem. J. 283 (1): 119-122. PMID 1567358.
^ ^a ^b Lombardo, D. (2001). "Bile salt-dependent lipase: its pathophysiological implications". Biochim. Biophys. Acta. 1533 (1): 1-28. PMID 11514232.
^ Sbarra V, Bruneau N. et al (1998). "Molecular cloning of the bile salt-dependent lipase of ferret lactating mammary gland: an overview of functional residues". Biochim. Biophys. Acta. 1393 (1): 80-89. PMID 9714751.

v • d • e Hydrolase: esterases (EC 3.1)
3.1.1: Carboxylic ester hydrolases	Cholinesterase - Pectinesterase - 6-phosphogluconolactonase - PAF acetylhydrolase Lipase (Gastric/Lingual, Pancreatic, Lysosomal, Hormone-sensitive, Endothelial, Hepatic, Lipoprotein, Monoacylglycerol, Diacylglycerol) Phospholipase (A1, A2, B)
3.1.2: Thioesterase	Palmitoyl thioesterase - Ubiquitin carboxy-terminal hydrolase L1
3.1.3: Phosphatase	Alkaline phosphatase - Acid phosphatase (Prostatic)/Tartrate resistant acid phosphatase/Purple acid phosphatases - Nucleotidase - Glucose 6-phosphatase - Fructose 1,6-bisphosphatase - Calcineurin - Phosphoprotein phosphatase (PP2A) - OCRL - Pyruvate dehydrogenase phosphatase - Fructose 2,6-bisphosphatase - Protein tyrosine phosphatase - PTEN
3.1.4: Phosphodiesterase	Autotaxin - Phospholipase (C, D) - Sphingomyelin phosphodiesterase - PDE1 - PDE2 - PDE3 - PDE5
3.1.6: Sulfatase	Arylsulfatase B - Steroid sulfatase - Galactosamine-6 sulfatase - Arylsulfatase A - Iduronate-2-sulfatase - N-acetylglucosamine-6-sulfatase
other	Nuclease

Categories: Genes on chromosome 9 | Enzymes

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Bile_salt_dependent_lipase". A list of authors is available in Wikipedia.