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Benzatropine
Benzatropine mesilate (INN, more commonly known as benztropine; marketed as Cogentin) is an anticholinergic drug principally used for the treatment of:
Additional recommended knowledgeBenztropine is a centrally acting anticholinergic agent with antihistaminic properties resulting from the combination of the tropine portion of the atropine molecule and the benzohydryl portion of diphenhydramine. Animal studies have indicated that anticholinergic activity of benztropine is approximately one-half that of atropine, while antihistaminic activity approaches that of pyrilamine. Its anticholinergic effects have been established as therapeutically significant in the management of parkinsonism. Benztrop antagonises the effect of acetylcholine, decreasing the imbalance between the neurotransmitters acetylcholine and dopamine, which may improve the symptoms of early Parkinson's disease. [1]
IndicationsIt is used in patients to reduce the side effects of antipsychotic treatment, such as parkinsonism and akathisia. Benztropine is also a second-line drug for the treatment of Parkinson's disease. It improves tremor but not rigidity or bradykinesia. Benztropine is also sometimes used for the treatment of dystonia, a rare disorder that causes abnormal muscle contraction, resulting in twisting postures of limbs, trunk, or face. Side effectsThese are principally anticholinergic:
Some studies suggest that use of anticholinergics increases the risk of tardive dyskinesia, a long-term side effect of antipsychotics.[2][3] Other studies have found no association between anticholinergic exposure and risk of developing tardive dyskinesia.[4] References
Categories: Anticholinergics | Dopamine reuptake inhibitors | Muscarinic antagonists | Tardive dyskinesia |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Benzatropine". A list of authors is available in Wikipedia. |