Bemotrizinol

Bemotrizinol (USAN^[1], Tinosorb® S, INCI Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine) is an oil soluble chemical which is added to sunscreens to absorb UV rays. It's marketed by Ciba Specialty Chemicals. It is a broad spectrum UV absorber, absorbing UVB as well as UVA rays. Bemotrizinol is highly photostable. Even after 50 MED (minimal edemal dose) 98.4% remains intact. It helps prevent photodegradation of other sunscreen actives.^[2]

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Bemotrizinol is not approved by the United States Food and Drug Administration, but is approved in the European Union since the year 2000^[3] and other parts of the world, including Australia.^[4][5]

Unlike some other organic sunscreen actives, it shows no estrogenic effects in vitro.^[6]

See also

• Sunscreen
• Avobenzone

References

1. ^ http://www.ama-assn.org/ama1/pub/upload/mm/365/bemotrizinol.doc
2. ^ Chatelain E, Gabard B. (Sep 2001). "Photostabilization of Butyl methoxydibenzoylmethane (Avobenzone) and Ethylhexyl methoxycinnamate by Bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S), a new UV broadband filter". Photochem Photobiol 74(3): 401-6. PMID 11594052.
3. ^ http://www.springerlink.com/content/6myjq6qa8l52cegv
4. ^ NEW-WAVE SUNSCREENS: Active ingredient makers are frustrated by the long list of sunscreens and UV-A testing protocols that are still awaiting FDA decisions, Chemical & Engineering News, April 11, 2005, Volume 83, Number 15, pp. 18-22. Online version
5. ^ http://www.tga.gov.au/docs/pdf/argom_10.pdf
6. ^ Ashby J, Tinwell H, Plautz J, Twomey K, Lefevre PA (Dec 2001). "Lack of binding to isolated estrogen or androgen receptors, and inactivity in the immature rat uterotrophic assay, of the ultraviolet sunscreen filters Tinosorb M-active and Tinosorb S". Regul Toxicol Pharmacol 34(3): 287-91. PMID 11754532.