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Balsalazide



Balsalazide
Systematic (IUPAC) name
5-[4-(2-carboxyethylcarbamoyl)phenyl]diazenyl-2-hydroxy-benzoic acid
Identifiers
CAS number 80573-04-2
ATC code A07EC04
PubChem 5362070
DrugBank APRD00141
Chemical data
Formula C17H15N3O6 
Mol. mass 357.318 g/mol
Pharmacokinetic data
Bioavailability <1%
Protein binding ≥99%
Metabolism  ?
Half life 12hr
Excretion  ?
Therapeutic considerations
Pregnancy cat.

B(US)

Legal status

POM [UK]

Routes  ?

Balsalazide is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease. It is sold under the name "Colazal" in the US and "Colazide" in the UK.

The chemical name is (E)-5-[[-4-(2-carboxyethyl) aminocarbonyl] phenyl]azo] -2-hydroxybenzoic acid. It is usually administered as the disodium salt.

Balsalazide releases mesalazine, also known as 5-aminosalicylic acid, or 5-ASA, in the large intestine. Its advantage over that drug in the treatment of Ulcerative colitis is believed to be the delivery of the active agent past the small intestine to the large intestine, the active site of ulcerative colitis.

v • d • e
Antidiarrheals, intestinal anti-inflammatory/anti-infective agents (A07)
Intestinal anti-infectivesAntibiotics (Neomycin, Nystatin, Natamycin, Streptomycin, Polymyxin B, Paromomycin, Amphotericin B, Kanamycin, Vancomycin, Colistin, Rifaximin)

Sulfonamides (Phthalylsulfathiazole, Sulfaguanidine, Succinylsulfathiazole)

other (Miconazole, Broxyquinoline, Acetarsol, Nifuroxazide, Nifurzide)
Intestinal adsorbentsCharcoal - Bismuth - Pectin - Kaolin - Crospovidone - Attapulgite - Diosmectite
AntipropulsivesDiphenoxylate - Opium - Loperamide - Difenoxin
Intestinal anti-inflammatory agentscorticosteroids acting locally (Prednisolone, Hydrocortisone, Prednisone, Betamethasone, Tixocortol, Budesonide, Beclometasone)

antiallergic agents, excluding corticosteroids (Cromoglicic acid)

aminosalicylic acid and similar agents (Sulfasalazine, Mesalazine, Olsalazine, Balsalazide)
Antidiarrheal micro-organismsSaccharomyces boulardii
Other antidiarrhealsAlbumin tannate - Ceratonia - Racecadotril
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Balsalazide". A list of authors is available in Wikipedia.
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