BMPR1A

The BMPR1A receptor binds BMP2 and BMP4. BMP's repress WNT signaling to maintain stable stem cell populations. BMPR1A null mice died at embyonic day 8.0 without mesoderm specification, demonstrating its vital role in gastrulation^[1]. It has been demonstrated in experiments using dominant negative BMPR1A chick embryos that BMPR1A plays a role in apoptosis and adipocyte development^[1]. Using constitutively active forms of BMR1A it has been shown that it plays a role in cell differentiation^[1]. Signals tranduced by the BMPR1A receptor are not essential for osteoblast formation or proliferation; however, BMPR1A is necessary for the extracellular matrix depostition by osteoblasts^[1]. In the chick embryo, BMPR1A receptors are found in low levels in limb bud mesenchyme, a differing location to BMPR1B, supporting the differing roles they play in osteogenesis^[2].

Diseases

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BMPR1A, SMAD4 and PTEN are responsible for Juvenile polyposis syndrome, juvenile intestinal polyposis and Cowden's disease.

References

1. ^ ^{a b c d} Mishina, Y; Starbuck MW, Gentile MA, Fukuda T, Kasparcova V, Seedor JG, Hanks MC, Amling M, Pinero GJ, Harada S, Behringer RR (Jun 2004). "Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling". J Biol Chem. 279 (26). Entrez PubMed 15090551. Retrieved on 2006-07-03.
2. ^ Yoon, BS; Ovchinnikov DA, Yoshii I, Mishina Y, Behringer RR, Lyons KM. (Apr 2005). "Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo". Proc Natl Acad Sci U S A. 102 (14). Entrez PubMed 15781876. Retrieved on 2006-07-03.