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Aminophylline


Aminophylline
Systematic (IUPAC) name
1,3-dimethyl-7H-purine-2,6-dione; ethane-1,2-diamine
Identifiers
CAS number	317-34-0
ATC code	R03DA05
PubChem	9433
DrugBank	APRD00329
Chemical data
Formula	C₁₆H₂₄N₁₀O₄
Mol. mass	420.427 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	60%
Metabolism	?
Half life	7-9 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	P(UK)
Routes	oral, i.v.

Aminophylline is a drug combination that contains theophylline and ethylenediamine in 2:1 ratio.

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Properties

It is more soluble in water than theophylline. White or slightly yellowish granules or powder, having a slight ammoniacal odor and a bitter taste. Upon exposure to air, it gradually loses ethylenediamine and absorbs carbon dioxide with the liberation of free theophylline. Its solutions are alkaline. One g dissolves in 25 mL of water to give a clear solution; 1 g dissolved in 5 mL of water crystallizes upon standing, but redissolves when a small amount of ethylenediamine is added. Insoluble in alcohol and in ether.

Mechanism of action

Aminophylline is less potent and shorter-acting than theophylline. Its most common use is in the treatment of bronchial asthma.

Brand names

Phyllocontin
Truphylline

v • d • e Drugs for obstructive airway diseases: asthma/COPD (R03)
Adrenergics, inhalants	Short acting β₂-agonists: Salbutamol/Levosalbutamol • Fenoterol • Terbutaline Long acting β₂-agonists (LABA): Bambuterol • Clenbuterol • Formoterol • Salmeterol other: Epinephrine • Isoproterenol • Orciprenaline
Glucocorticoids	Beclometasone • Budesonide • Ciclesonide • Fluticasone • Mometasone
Anticholinergics	Ipratropium • Tiotropium
Mast cell stabilizers	Cromoglicate • Nedocromil
Xanthines	Aminophylline • Theobromine • Theophylline
Leukotriene antagonists	Montelukast • Pranlukast • Zafirlukast
Combination products	Budesonide/formoterol • Fluticasone/salmeterol • Ipratropium/salbutamol