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Alpha-7 nicotinic receptor



The alpha-7 nicotinic receptor (α7)5 is a type of nicotinic acetylcholine receptor, consisting entirely of α7 subunits [1].

It is located in the brain, where activation yields post- and presynaptic excitation[1], mainly by increased Ca2+ permeability.

Agonists

Nicotinic agonists for this receptor include:

Antagonists

  • mecamylamine
  • α-bungarotoxin

alpha-conotoxin ArIB[V11L,V16D][2]

2. Whiteaker P, Christensen S, Yoshikami D, Dowell C, Watkins M, Gulyas J, Rivier J, Olivera BM, McIntosh JM. Discovery, synthesis, and structure activity of a highly selective alpha7 nicotinic acetylcholine receptor antagonist. Biochemistry. 2007 Jun 5;46(22):6628-38.

  1. ^ a b Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0443071454, 5:th ed., Churchill Livingstone 2003) Page 138.
v • d • e
Ion channel, receptor: ligand-gated ion channels
Cys-loop receptors5-HT receptor (5-HT3 serotonin receptor (A)) - GABA receptor (GABA A (α1, α2, α3, α5, α6, β1, β2, β3, γ2, ε), GABA C (ρ1)) - Glycine receptor (α1) - Nicotinic acetylcholine receptor (α1, α2, α3, α4, α5, α7, β2, β3, β4, δ, ε, (α4)2(β2)3, (α7)5, Ganglion type, Muscle type)
Ionotropic glutamate receptorsAMPA (1, 2, 3, 4) - Kainate (1, 2) - NMDA (1, 2A, 2B, 2C, 2D)
ATP-gated channelsPurinergic receptors (P2X (1, 4, 5, 7))
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Alpha-7_nicotinic_receptor". A list of authors is available in Wikipedia.
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