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Alclometasone



Alclometasone
Systematic (IUPAC) name
[7-chloro-11-hydroxy- 10,13,16-trimethyl-3-oxo-17- (2-propanoyloxyacetyl)- 7,8,9,11,12, 14,15,16- octahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate
Identifiers
CAS number 66734-13-2
ATC code D07AB10 S01BA10
PubChem 636374
DrugBank APRD00783
Chemical data
Formula C28H37ClO7 
Mol. mass 521.042 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes topical

Contents

Description

Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.
Alclometasone Dipropionate marketed as medication Aclovate by GlaxoSmithKline.

Pharmacology

Alclometasone inhibits phospholipase A2 by inducing production of lipocortins; inhibits synthesis of arachidonic acid, prostaglandins and leukotrienes acid, reduce release of cytokines from lymphocytes and others mediators of inflammation (incl. histamine).

Indications

Alclometasone cream and onintment are indicated for the relief of corticosteroid-responsive dermatoses, including:

  • atopic dermatitis
  • eczema
  • psoriasis
  • allergic dermatitis
  • contact dermatitis
  • actinic dermatitis
  • kiss-type allergy
  • skin itch
    Alclometasone may be used on sensetive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients.

    Contraindications

  • hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms
  • cutaneous tuberculosis
  • chicken pox
  • perioral dermatitis
  • acne
  • rosacea
  • open wounds
  • trophic ulcers
  • viral infection of skin
  • skin manifestations of syphilis

    Side effects

    Alclometasone Adverse reactions/Side effects (sometimes, less than 1-2% cases) include:

  • burning
  • itching
  • erythema
  • skin reddening
  • xerodermia
  • skin irritation
  • acne
  • hypopigmentation
  • prickly heat
  • folliculitis
  • white atrophy
  • hypertrichosis
  • reinfection of skin

    How supplied

    Alclometasone as Aclovate® is supplied in:

  • Cream; Topical; 0.05%
  • Ointment; Topical; 0.05%

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    This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Alclometasone". A list of authors is available in Wikipedia.
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