Agelasimines

Agelasimines are adenine-related bicyclic diterpenoids isolated from the orange sponge Agelas mauritania. Their chemical structures are closeley related to the agelasines.

Additional recommended knowledge

Safe Weighing Range Ensures Accurate Results

Daily Sensitivity Test

Daily Visual Balance Check

Both compounds display a range of biological activities, such as cytotoxicity, inhibition of adenosine transfer into rabbit erythrocytes (red blood cells), Ca²+ channel antagonistic action, ά1 adrenergic blockade and others.

Both compounds have been reproduced in the laboratory by organic synthesis.

References

• Fathi-Afshar R; Allen T M; Krueger C A; Cook D A; Clanachan A S; Vriend R; Baer H P; Cass C E, Canadian journal of physiology and pharmacology, 1989, 67(4), 276-81
• Fathi-Afshar, R.; Allen, T. M., Canadian Journal of Chemistry, 1988, 66(1), 45-50.
• Fathi-Afshar, R.; Allen, T. M.; Krueger, C. A.; Cook, D. A.; Clanachan, A. S.; Vriend, R.; Baer, H. P.; Cass, C. E., Canadian Journal of Physiology and Pharmacology, 1989, 67(4), 276-81.
• Ohba, Masashi; Iizuka, Kazuaki; Ishibashi, Hiroyuki; Fujii, Tozo., Tetrahedron 1997, 53(50), 16977-16986.