Adenylsuccinate

Adenylsuccinate is an intermediate in the intercoversion of purine nucleotides inosine monophosphate (IMP) and adenosine monophosphate (AMP). It is formed by the addition of aspartate to IMP and requires the input of energy from a phosphoanhydride bond in the form of Guanosine triphosphate (GTP). GTP is used instead of Adenosine triphosphate (ATP), so the reaction is not dependent on its products.

References

• See Figures 20.4 and 20.7 in Textbook of Biochemistry, with clinical correlations, Sixth Edition, Thomas M. Devlin, Ed., Wiley-Liss, Inc., New York, NY, 2006.