APC (protein)

APC (adenomatosis polyposis coli) is the product of a tumor suppressor gene (APC (gene)). The human full-length protein comprises 2843 AA with a (predicted) molecular mass of 311646 Da. Most domains of this protein are solved structurally and exhibit high intrinsic disorder/flexibility as monomer and a low content of stable secondary structure. Thus it is a member of the intrinsically unstructured proteins (Intrinsically unstructured proteins). Nothing is known about in vivo full-length (un)foldome which is nice for some investigators (but bad for current therapeutic intervention) ...

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List of (some ...) point mutants

L852M

P865S

S906Y

E911G

S966R

Y1027C

T1018C

S1081I

D1083E

Q1096H

E1284G

E1284K

A1305S

E1306K

K1308E

E1317Q

P1319T

S1321N

V1326M

E1353V

F1354L

G1357R

S1364R

Q1367H

P1373T

S1389F

S1389T

S1385R

L1393P

S1395C

S1398N

S1415I

D1422H

D1425A

S1434I

K1468N

G1534R

S1599L

References

Point mutants :

• PMID 12619115
• PMID 14695993
• PMID 1528264
• PMID 8395678
• PMID 12093899
• PMID 9924427
• PMID 15072829
• PMID 12833148
• PMID 8764128
• PMID 11315765
• PMID 10638959
• PMID 11819789
• PMID 8055154
• PMID 9014854
• PMID 11048797
• PMID 7881432
• PMID 9482574
• PMID 14502807
• PMID 17882487

External links

• Database concerning peer-reviewed reports on cancer critical alteration in several genes including (APC (protein)), (TP53), (ß-catenin)