Mutabilis SA

Mutabilis is a privately-held French biopharmaceutical company developing novel non-beta-lactam PBP-targeting antibacterial drugs called dabocins to treat the most difficult-to-treat Gram-negative bacterial infections. Dabocins are derived from the non-natural diazabicyclooctane scaffold and show a remarkable stability to beta-lactamase hydrolysis. Mutabilis' team has unique expertise in the derivatization and characterization of this scaffold. Mutabilis' pipeline includes EBL-1463, a novel single-agent intravenous antibiotic against carbapenem-resistant Enterobacterales also supported by ENABLE (ND4BB/IMI), and 2G-DAB, a 2nd generation dabocin program supported by the Repair Impact Fund and which aims to discover the next generation dabocin covering both Enterobacterales and non-fermenters.