Reservoir Neuroscience, Inc.

Reservoir Neuroscience is an early-stage, San Fransisco Bay Area venture-backed biotech advancing a novel therapy to reverse brain vascular pathology in aging and neurodegenerative diseases. In these critically unmet diseases, the brain’s blood vessels become damaged and dysfunctional, causing inflammation that drives disease outcomes. This vascular pathology is the earliest biomarker of neurodegeneration and defines the largest segment, yet has never been treated.

Reservoir Neuroscience is led by co-founders Aaron Friedman and Vlad Senatorov, PhD neuroscientists from UC Berkeley who pioneered new research uncovering how blood vessel aging causes brain disease. Reservoir Neuroscience developed a proprietary human organ chip platform to discover novel, class-leading compounds that restore brain vascular health, offering a first-in-kind approach to reverse vascular pathology and neuroinflammation.