Ultra-sensitive Biomarker Quantification in Microsampling Support
New perspectives in analyte quantification by fine-tuning between sensitivity and sample consumption
Biomarker quantification in microsampling support is an emerging field in pre-clinical studies. While sample volumes of 10 µl may be sufficient for PK studies to determine drug concentration in ng/ml range, multiparameter quantification of low abundant endogenous biomarker (typically low pg/ml range) in ligand-binding assay (LBA) microsampling support is challenging. A major hurdle is the correlation of required sample volume vs. assay sensitivity on most immune-assay platforms. Due to exponential signal amplification, Imperacer® Immuno-PCR (IPCR) technology enables ultra-sensitive biomarker determination in microsampling support with excellent sensitivities at low per-run sample-consumption. Furthermore, Imperacer® enables fine-tuning of required sensitivity vs. sample volume towards the needs of specific study support. Here we utilized Imperacer® Immuno-PCR (IPCR) for quantification of low abundant biomarker in sub pg/ml range with less than 10 µl total sample consumption in duplicate runs.
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Ultra-sensitive Biomarker Quantification in Microsampling Support
New perspectives in analyte quantification by fine-tuning between sensitivity and sample consumption
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This groundbreaking and highly versatile molecular technique of PCR allows us to amplify tiny amounts of genetic material on a large scale and analyze them in detail. Whether in medical diagnostics, forensic DNA analysis or research into genetic diseases - PCR is an indispensable tool that gives us deep insights into the world of DNA. Immerse yourself in the fascinating world of the polymerase chain reaction (PCR)!
Topic World PCR
This groundbreaking and highly versatile molecular technique of PCR allows us to amplify tiny amounts of genetic material on a large scale and analyze them in detail. Whether in medical diagnostics, forensic DNA analysis or research into genetic diseases - PCR is an indispensable tool that gives us deep insights into the world of DNA. Immerse yourself in the fascinating world of the polymerase chain reaction (PCR)!